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Photochemistry is a powerful tool for synthesizing important molecules which are challenging to create without light. We report compelling results which indicate that photochemical reaction rates (oxygenation and cycloaddition) can be notably enhanced by utilizing a very small number of entangled photons. Measurements with the same small number of classical photons show the rate of product formation is considerably lower. This suggests that the reaction rate with entangled photons is enhanced by many orders of magnitude. Theoretical calculations show that classical photons and entangled photons excite the photocatalyst to different final excited states. This chemical synthesis approach with entangled photons could have a large impact on our understanding of chemical reactivity and provide new insights into photochemical processes.more » « lessFree, publicly-accessible full text available May 8, 2026
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